Exploration
Accueil
Racine
Exploration
Accueil
Racine

Serveur sur les données et bibliothèques médicales au Maghreb (version finale)

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies

Identifieur interne : 000074 ( Main/Exploration ); précédent : 000073; suivant : 000075

Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies

Auteurs : Oussama Kebir ; Karim Tabbane ; Sarojini Sengupta ; Ridha Joober

Source :

RBID : PMC:2647566

Descripteurs français

English descriptors

Abstract

Background

We reviewed systematically the results of genetic studies investigating associations between putative susceptibility genes for attention-deficit hyperactivity disorder (ADHD) and neuropsychological traits relevant for this disorder.

Methods

We identified papers for review through the PubMed database.

Results

Twenty-nine studies examined 10 genes (DRD4, DAT1, COMT, DBH, MAOA, DRD5, ADRA2A, GRIN2A, BDNF and TPH2) in relation to neuropsychological traits relevant for ADHD. For DRD4, the continuous performance test (CPT) and derived tasks were the most used tests. Association of high reaction time variability with the 7-repeat allele absence appears to be the most consistent result and seems to be specific to ADHD. Speed of processing, set-shifting and cognitive impulsiveness were less frequently investigated but seem to be altered in the 7-repeat allele carriers. No effect of genotype was found on response inhibition (the stop and go/no-go tasks). For DAT1, 4 studies provide conflicting results in relation to omission and commission errors from CPT and derived tasks. High reaction time variability seems to be the most replicated cognitive marker associated with the 10-repeat homozygosity. The other genes have attracted fewer studies, and the reported findings need to be replicated.

Limitations

Although we aimed to perform a formal meta-analysis, this was not possible because the number of studies using the same neurocognitive endophenotypes was limited. We referred only minimally to the various theoretical frameworks in this field of research; more detail would have been beyond the scope of our systematic review. Finally, sample sizes in most of the studies we reviewed were small. Thus, some negative findings could be attributed to a lack of statistical power, and positive results should be considered preliminary until they are replicated in extended samples.

Conclusion

Several methodological issues, including measurement errors, developmental changes in cognitive abilities, sex, psychostimulant effects and presence of comorbid conditions, represent confounding factors and may explain conflicting results.


Url:
PubMed: 19270759
PubMed Central: 2647566


Affiliations:

Links toward previous steps (curation, corpus...)

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies</title>
<author>
<name sortKey="Kebir, Oussama" sort="Kebir, Oussama" uniqKey="Kebir O" first="Oussama" last="Kebir">Oussama Kebir</name>
</author>
<author>
<name sortKey="Tabbane, Karim" sort="Tabbane, Karim" uniqKey="Tabbane K" first="Karim" last="Tabbane">Karim Tabbane</name>
</author>
<author>
<name sortKey="Sengupta, Sarojini" sort="Sengupta, Sarojini" uniqKey="Sengupta S" first="Sarojini" last="Sengupta">Sarojini Sengupta</name>
</author>
<author>
<name sortKey="Joober, Ridha" sort="Joober, Ridha" uniqKey="Joober R" first="Ridha" last="Joober">Ridha Joober</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">19270759</idno>
<idno type="pmc">2647566</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647566</idno>
<idno type="RBID">PMC:2647566</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">000104</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000104</idno>
<idno type="wicri:Area/Pmc/Curation">000104</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000104</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000306</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000306</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:19270759</idno>
<idno type="wicri:Area/PubMed/Corpus">000745</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000745</idno>
<idno type="wicri:Area/PubMed/Curation">000741</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000741</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000745</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000745</idno>
<idno type="wicri:Area/Main/Merge">000074</idno>
<idno type="wicri:Area/Main/Curation">000074</idno>
<idno type="wicri:Area/Main/Exploration">000074</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies</title>
<author>
<name sortKey="Kebir, Oussama" sort="Kebir, Oussama" uniqKey="Kebir O" first="Oussama" last="Kebir">Oussama Kebir</name>
</author>
<author>
<name sortKey="Tabbane, Karim" sort="Tabbane, Karim" uniqKey="Tabbane K" first="Karim" last="Tabbane">Karim Tabbane</name>
</author>
<author>
<name sortKey="Sengupta, Sarojini" sort="Sengupta, Sarojini" uniqKey="Sengupta S" first="Sarojini" last="Sengupta">Sarojini Sengupta</name>
</author>
<author>
<name sortKey="Joober, Ridha" sort="Joober, Ridha" uniqKey="Joober R" first="Ridha" last="Joober">Ridha Joober</name>
</author>
</analytic>
<series>
<title level="j">Journal of Psychiatry & Neuroscience : JPN</title>
<idno type="ISSN">1180-4882</idno>
<idno type="eISSN">1488-2434</idno>
<imprint>
<date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Attention Deficit Disorder with Hyperactivity (genetics)</term>
<term>Attention Deficit Disorder with Hyperactivity (psychology)</term>
<term>Child (MeSH)</term>
<term>Gene Frequency (MeSH)</term>
<term>Genome-Wide Association Study (MeSH)</term>
<term>Humans (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Enfant (MeSH)</term>
<term>Fréquence d'allèle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Trouble déficitaire de l'attention avec hyperactivité (génétique)</term>
<term>Trouble déficitaire de l'attention avec hyperactivité (psychologie)</term>
<term>Étude d'association pangénomique (MeSH)</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Attention Deficit Disorder with Hyperactivity</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Trouble déficitaire de l'attention avec hyperactivité</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr">
<term>Trouble déficitaire de l'attention avec hyperactivité</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en">
<term>Attention Deficit Disorder with Hyperactivity</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Child</term>
<term>Gene Frequency</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Enfant</term>
<term>Fréquence d'allèle</term>
<term>Humains</term>
<term>Étude d'association pangénomique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec>
<title>Background</title>
<p>We reviewed systematically the results of genetic studies investigating associations between putative susceptibility genes for attention-deficit hyperactivity disorder (ADHD) and neuropsychological traits relevant for this disorder.</p>
</sec>
<sec>
<title>Methods</title>
<p>We identified papers for review through the PubMed database.</p>
</sec>
<sec>
<title>Results</title>
<p>Twenty-nine studies examined 10 genes (DRD4, DAT1, COMT, DBH, MAOA, DRD5, ADRA2A, GRIN2A, BDNF and TPH2) in relation to neuropsychological traits relevant for ADHD. For DRD4, the continuous performance test (CPT) and derived tasks were the most used tests. Association of high reaction time variability with the 7-repeat allele absence appears to be the most consistent result and seems to be specific to ADHD. Speed of processing, set-shifting and cognitive impulsiveness were less frequently investigated but seem to be altered in the 7-repeat allele carriers. No effect of genotype was found on response inhibition (the stop and go/no-go tasks). For DAT1, 4 studies provide conflicting results in relation to omission and commission errors from CPT and derived tasks. High reaction time variability seems to be the most replicated cognitive marker associated with the 10-repeat homozygosity. The other genes have attracted fewer studies, and the reported findings need to be replicated.</p>
</sec>
<sec>
<title>Limitations</title>
<p>Although we aimed to perform a formal meta-analysis, this was not possible because the number of studies using the same neurocognitive endophenotypes was limited. We referred only minimally to the various theoretical frameworks in this field of research; more detail would have been beyond the scope of our systematic review. Finally, sample sizes in most of the studies we reviewed were small. Thus, some negative findings could be attributed to a lack of statistical power, and positive results should be considered preliminary until they are replicated in extended samples.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>Several methodological issues, including measurement errors, developmental changes in cognitive abilities, sex, psychostimulant effects and presence of comorbid conditions, represent confounding factors and may explain conflicting results.</p>
</sec>
</div>
</front>
</TEI>
<affiliations>
<list></list>
<tree>
<noCountry>
<name sortKey="Joober, Ridha" sort="Joober, Ridha" uniqKey="Joober R" first="Ridha" last="Joober">Ridha Joober</name>
<name sortKey="Kebir, Oussama" sort="Kebir, Oussama" uniqKey="Kebir O" first="Oussama" last="Kebir">Oussama Kebir</name>
<name sortKey="Sengupta, Sarojini" sort="Sengupta, Sarojini" uniqKey="Sengupta S" first="Sarojini" last="Sengupta">Sarojini Sengupta</name>
<name sortKey="Tabbane, Karim" sort="Tabbane, Karim" uniqKey="Tabbane K" first="Karim" last="Tabbane">Karim Tabbane</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/MaghrebDataLibMedV2/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000074 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000074 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    MaghrebDataLibMedV2
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:2647566
   |texte=   Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:19270759" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MaghrebDataLibMedV2
Wicri

This area was generated with Dilib version V0.6.38.
Data generation: Wed Jun 30 18:27:05 2021. Site generation: Wed Jun 30 18:34:21 2021